Precision Periodontology: Promise, Practicality and Clinical Reality
Keywords:
Precision medicine, Personalized therapy, Periodontal disease, Biomarkers, Microbiome, Risk assessmentAbstract
The concept of precision periodontology is based on treatment strategies from population-based protocols to individualized care. Traditionally periodontal approach guided by standardized mechanical and surgical approach resulting in shifting of paradigm. Precision periodontology proposed preventive, diagnostic, and therapeutic interventions based on individual’s genetic profile, microbial flora, systemic health status and behavioural risk factors. While the scientific foundation supporting personalized periodontal care is expanding with significant clinical and logistical barriers remain. This opinion article explores the conceptual basis, clinical relevance, challenges, and future implications of precision periodontology arguing its integration into routine practice must be evidence-driven and pragmatically implemented.
References
Gundelly M, Pusuluri SV, Koduganti RR, Ambati M, Chiluveru S, Chandaka M. Precision Medicine in Periodontics: A Literature Review. Cureus. 2024;16(9):e68952.
Dong A, Proctor G, Zaric S. Diagnostic Accuracy of Microbiome-Derived Biomarkers in Periodontitis: Systematic Review and Meta-Analysis. J Periodontal Res. 2025;60(8):748–761.
Radu CM, Radu CC, Zaha DC. Salivary and Microbiome Biomarkers in Periodontitis: Advances in Diagnosis and Therapy—A Narrative Review. Medicina (Kaunas). 2025;61(10):1818.
Dommisch H, Hoedke D, Lu EM-C, Schäfer A, Richter G, Kang J, et al. Genetic Biomarkers for Periodontal Diseases: A Systematic Review. J Clin Periodontol. 2025;52 Suppl 29(Suppl 29):182–210.
Bostanci N, Manoil D, Van Holm W, Belibasakis GN, Teughels W. Microbial Markers for Diagnosis and Risk Assessment for Periodontal Diseases: A Systematic Literature Search and Narrative Synthesis. J Clin Periodontol. 2025;52 Suppl 29(Suppl 29):125–154.
Pitchika V, Büttner M, Schwendicke F. Artificial intelligence and personalized diagnostics in periodontology: A narrative review. Periodontol 2000. 2024;95(1):220–231.
Dipalma G, Inchingolo AM, Inchingolo F, Palumbo I, Riccaldo L, Guglielmo M, et al. The Precision Paradigm in Periodontology: A Multilevel Framework for Tailored Diagnosis, Treatment, and Prevention. J Pers Med. 2025;15(9):440.
Selvaraj S, Kumar SM. Customized Periodontics: A Blueprint for Accurate Periodontal Treatment – A Narrative Review. IJRDO J Appl Sci. 2025;11(5):11–17.
Chew RJ, Goh CE, Sriram G, Preshaw PM, Tan KS. Microbial biomarkers as a predictor of periodontal treatment response: A systematic review. J Periodontal Res. 2023;58(6):1113–1127.
Anil A, Balakrishnan KVAB, Peter MR, Suresh R. Precision Periodontics – A Review. J Transl Med Transplant Res. 2024; 3:112.
