PROBIOTICS AND THE MICROBIOME: THERAPEUTIC POTENTIAL AND MECHANISMS OF ACTION
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Abstract
Healthcare research has identified the probabilistic interplay between probiotics and human microbiomes as an emerging promising field which shows therapeutic potential in various health conditions. This assessment investigates how probiotics work through their impact on microbiome regulation and their effects on immune responses and their ability to communicate across the gut-brain axis. Clinical evidence shows that probiotics successfully treat gastrointestinal diseases and strengthen immunity systems and help control metabolism and protect oral health and improve mental well-being. The promising research outcomes encounter major obstacles because of strain-specific discrepancies alongside inadequate standardized methods together with insufficient high-quality clinical research findings. Advanced methods in research and personalized treatment strategies combined with standard regulations will establish optimal methods for using probiotics. The growing understanding of the microbiome indicates that probiotics will assume a vital position in future medical strategies as natural preventive solutions because of their effectiveness in health management. The review summarizes existing research knowledge together with future guidance required to maximize their potential.
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References
Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW. Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies. Chem Rev. 2023;123(1):31-72.
Oelschlaeger TA. Mechanisms of probiotic actions–a review. International journal of medical microbiology. 2010;300(1):57-62.
Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic mechanisms of action. Annals of Nutrition and Metabolism. 2012;61(2):160-74.
Nithya A, Misra S, Panigrahi C, Dalbhagat CG, Mishra HN. Probiotic potential of fermented foods and their role in non-communicable diseases management: An understanding through recent clinical evidences. Food Chemistry Advances. 2023; 3:100381.
Leonard JM, Toro DD. Defining the Microbiome Components (Bacteria, Viruses, Fungi) and Microbiome Geodiversity. Surg Infect (Larchmt). 2023;24(3):208-12.
Portincasa P, Bonfrate L, Vacca M, De Angelis M, Farella I, Lanza E, et al. Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis. Int J Mol Sci. 2022;23(3).
Colella M, Charitos IA, Ballini A, Cafiero C, Topi S, Palmirotta R, et al. Microbiota revolution: How gut microbes regulate our lives. World J Gastroenterol. 2023;29(28):4368-83.
Gupta S, Allen-Vercoe E, Petrof EO. Fecal microbiota transplantation: in perspective. Therap Adv Gastroenterol. 2016;9(2):229-39.
Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nature medicine. 2018;24(4):392-400.
Rajasekaran JJ, Krishnamurthy HK, Bosco J, Jayaraman V, Krishna K, Wang T, et al. Oral Microbiome: A Review of Its Impact on Oral and Systemic Health. Microorganisms. 2024;12(9).
Deo PN, Deshmukh R. Oral microbiome: Unveiling the fundamentals. J Oral Maxillofac Pathol. 2019;23(1):122-8.
Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL. The oral microbiome: Role of key organisms and complex networks in oral health and disease. Periodontol 2000. 2021;87(1):107-31.
Li X, Liu Y, Yang X, Li C, Song Z. The Oral Microbiota: Community Composition, Influencing Factors, Pathogenesis, and Interventions. Front Microbiol. 2022;13:895537.
Santacroce L, Passarelli PC, Azzolino D, Bottalico L, Charitos IA, Cazzolla AP, et al. Oral microbiota in human health and disease: A perspective. Exp Biol Med (Maywood). 2023;248(15):1288-301.
Mark Welch JL, Ramírez-Puebla ST, Borisy GG. Oral Microbiome Geography: Micron-Scale Habitat and Niche. Cell Host & Microbe. 2020;28(2):160-8.
Di Stefano M, Polizzi A, Santonocito S, Romano A, Lombardi T, Isola G. Impact of Oral Microbiome in Periodontal Health and Periodontitis: A Critical Review on Prevention and Treatment. Int J Mol Sci. 2022;23(9).
Latif A, Shehzad A, Niazi S, Zahid A, Ashraf W, Iqbal MW, et al. Probiotics: mechanism of action, health benefits and their application in food industries. Front Microbiol. 2023; 14:1216674.
Zendeboodi F, Khorshidian N, Mortazavian AM, da Cruz AG. Probiotic: conceptualization from a new approach. Current Opinion in Food Science. 2020; 32:103-23.
Wang X, Zhang P, Zhang X. Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity. Molecules. 2021;26(19).
Chandrasekaran P, Weiskirchen S, Weiskirchen R. Effects of Probiotics on Gut Microbiota: An Overview. Int J Mol Sci. 2024;25(11).
Mazziotta C, Tognon M, Martini F, Torreggiani E, Rotondo JC. Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health. Cells. 2023;12(1).
Gou HZ, Zhang YL, Ren LF, Li ZJ, Zhang L. How do intestinal probiotics restore the intestinal barrier? Front Microbiol. 2022; 13:929346.
Yang SC, Lin CH, Sung CT, Fang JY. Antibacterial activities of bacteriocins: application in foods and pharmaceuticals. Front Microbiol. 2014; 5:241.
Markowiak-Kopeć P, Śliżewska K. The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome. Nutrients. 2020;12(4).
Ansari F, Neshat M, Pourjafar H, Jafari SM, Samakkhah SA, Mirzakhani E. The role of probiotics and prebiotics in modulating of the gut-brain axis. Front Nutr. 2023;10:1173660.
Inchingolo F, Inchingolo AM, Malcangi G, De Leonardis N, Sardano R, Pezzolla C, et al. The Benefits of Probiotics on Oral Health: Systematic Review of the Literature. Pharmaceuticals (Basel). 2023;16(9).
Bizzini B, Pizzo G, Scapagnini G, Nuzzo D, Vasto S. Probiotics and oral health. Curr Pharm Des. 2012;18(34):5522-31.
Gul S, Durante-Mangoni E. Unraveling the Puzzle: Health Benefits of Probiotics—A Comprehensive Review. Journal of Clinical Medicine. 2024;13(5):1436.
Ursell LK, Metcalf JL, Parfrey LW, Knight R. Defining the human microbiome. Nutrition reviews. 2012;70(suppl_1):S38-S44.
Abouelela ME, Helmy YA. Next-Generation Probiotics as Novel Therapeutics for Improving Human Health: Current Trends and Future Perspectives. Microorganisms. 2024;12(3).
Didari T, Mozaffari S, Nikfar S, Abdollahi M. Effectiveness of probiotics in irritable bowel syndrome: Updated systematic review with meta-analysis. World J Gastroenterol. 2015;21(10):3072-84.
Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Nageshwar Reddy D. Role of the normal gut microbiota. World J Gastroenterol. 2015;21(29):8787-803.