Effect of Thiocin On Cholesterol Metabolism During the Progression of Experimental Atherosclerosis

Nuraliyeva Z.S.; Sabirova R.A.; Alimbekova L.U.

Authors

Nuraliyeva Z.S. Independent Researcher of the Department of Medical and Biological Chemistry No. 1, Tashkent State Medical University, Uzbekistan
Sabirova R.A. Doctor of Medical Sciences, Professor of the Department of Medical and Biological Chemistry No. 1, Tashkent State Medical University, Uzbekistan
Alimbekova L.U. Assosiate professor of the the Department of Medical and Biological Chemistry No. 1, Tashkent State Medical University, PhD, Uzbekistan

Keywords:

Atherosclerosis, cholesterol, cortisol

Abstract

The effect of Thiocin on cholesterol metabolism parameters in experimental atherosclerosis was investigated. Experimental atherosclerosis was induced in rabbits by daily administration of cholesterol for three months. Experimental atherosclerosis was found to be associated with marked hypercholesterolemia and decreased serum cortisol and vitamin D levels. Thiocin exerted a pronounced dose-dependent hypocholesterolemic effect and promoted an increase in cortisol levels. The most pronounced therapeutic effect was observed with Thiocin administered at a dose of 70 mg/kg and in combination with Levazo. The effect of Thiocin on vitamin D levels was less pronounced.

References

Anichkov NN, Khalatov SS. New data on the pathology and etiology of atherosclerosis. Russkii Vrach [Russian Physician]. 1913;(8):184-186.

Bikle DD. Vitamin D: Production, Metabolism and Mechanisms of Action. In: Endotext. South Dartmouth (MA): MDText.com, Inc.; 2023.

Bouillon R. Vitamin D and extraskeletal health: an update. Endocrine. 2022.

Hannibal KE, Bishop MD. Chronic stress, cortisol dysfunction, and pain: A psychoneuroendocrine rationale for stress management in pain rehabilitation. Phys Ther. 2024.

Jiang H, et al. Mechanisms of Oxidized LDL-Mediated Endothelial Dysfunction and Atherosclerosis. Front Cardiovasc Med. 2022;9:925923.

Kivimäki M, Steptoe A. Effects of stress on the development and progression of cardiovascular disease. Nat Rev Cardiol. 2018;15(4):215-229. doi:10.1038/nrcardio.2017.189.

Linton MRF, Yancey PG, Davies SS, et al. The Role of Lipids and Lipoproteins in Atherosclerosis. In: Endotext. South Dartmouth (MA): MDText.com, Inc.; 2019.

Nedkoff L., Briffa T., Zemedikun D., et al. Global Trends in Atherosclerotic Cardiovascular Disease. Current Atherosclerosis Reports. 2023.

Pilz S, März W, Cashman KD, Kiely ME, Whiting SJ, Holick MF, et al. Vitamin D and cardiovascular disease prevention. Nat Rev Cardiol. 2023.

Pilz S, März W, et al. Vitamin D and cardiovascular disease prevention. Nat Rev Cardiol. 2023.

Powell-Wiley TM, Poirier P, Burke LE, et al. Obesity and cardiovascular disease: A scientific statement from the American Heart Association. Circulation. 2021;143:e984-e1010.

Rhee EJ. Prevalence and Current Status of Cardiometabolic Risk Factors. Endocrinol Metab (Seoul). 2025

Russell G, Lightman SL. The human stress response. Nat Rev Endocrinol. 2019;15(9):525-534.

Swarup S, Goyal A, Grigorova Y, et al. Metabolic Syndrome. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.

Vekic J, Zeljkovic A, Stefanovic A, et al. Oxidative Stress, Atherogenic Dyslipidemia, and Cardiovascular Disease. Biomedicines. 2023;11(11):2897.

Wang TJ. Vitamin D and cardiovascular disease. Annu Rev Med. 2023.

Effect of Thiocin On Cholesterol Metabolism During the Progression of Experimental Atherosclerosis

Authors

Keywords:

Abstract

References

Downloads

Published

Issue

Section

Categories

License