Traumatic Ulcerative Granuloma with Stromal Eosinophilia of The Lateral Border of Tongue Mimicking Oral Squamous Cell Carcinoma: A Case Report

Abstract

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an uncommon benign inflammatory lesion of the oral mucosa characterized by persistent ulceration accompanied by a dense eosinophil-rich inflammatory infiltrate within the connective tissue. Clinically, the lesion often presents as a chronic indurated ulcer and may closely resemble oral squamous cell carcinoma, creating diagnostic uncertainty. Histopathologically, it typically shows ulcerated stratified squamous epithelium with a polymorphous inflammatory infiltrate predominantly composed of eosinophils extending into deeper connective tissue and skeletal muscle bundles. We report a case of a 75-year-old female presenting with a persistent ulcer on the right lateral border of the tongue associated with chronic mechanical irritation. The clinical, histopathological and follow-up findings were consistent with traumatic ulcerative granuloma with stromal eosinophilia, and the lesion resolved completely after elimination of the traumatic factor.