The Role of Serum IL-10 And IL-17 Levels in The Progression and Severity of Bacterial Pneumonia
Keywords:
IL-10, IL-17, Pneumonia, Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniaeAbstract
Background: Bacterial pneumonia is still a leading cause of global morbidity and mortality. Interleukin-10(IL-10) and interleukin-17(IL-17), two major cytokines participating in the anti-inflammatory and pro-inflammatory pathways. The objective of the study was to determine whether serum IL-10 and IL-17 acts as a noninvasive marker for bacterial pneumonia staging and severity. Methods: A case-control study was carried out at Al-Sadr Medical City, Al-Najaf, Iraq. This study enrolled 60 patients diagnosed as bacterial pneumonia (cases) and 40 apparently healthy controls. Serum IL-10 and IL-17 using Enzyme-linked immunosorbent assays (ELISA). According to the severity of illness, patients were divided into groups with mild, moderate and severe pneumonia. Results: Serum IL-10 and IL-17 levels in bacterial pneumonia patients were also significantly elevated when compared with healthy controls (P < 0.001). The average IL-10 level was 32.84 ± 8.71 pg/mL in patients vs. 12.63 ± 4.25 pg/mL in controls and the average IL-17 level was 48.57 ± 11.36 pg/mL vs. 18.92 ± 6.14 pg/mL, respectively. Moreover, both cytokines increased significantly with disease severity. Among the three groups, patients with severe pneumonia had the highest concentrations of IL-10 and IL-17 (P = 0.002 and P < 0.001, respectively). Conclusions: High serum IL-10 and IL-17 levels associated with bacterial pneumonia can be used as a significant correlate with severity of disease. Therefore, these results indicate that both cytokines should be helpful for predicting or evaluating the disease severity and disease course of patients with bacterial pneumonia.
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