The Emerging Role of Extracellular Vesicles Derived from Oral Bacteria in Periodontal Disease Progression and Systemic Inflammation
Keywords:
Extracellular vesicles, Oral bacteria, Periodontal disease, Inflammation, Toll-like receptors, BiomarkersAbstract
Extracellular vesicles derived from oral bacteria have recently been identified as central players in oral and systemic intercellular communication. These nanoscale particles are produced by commensal and pathogenic bacteria and carry a broad range of protein, lipid, and nucleic- acid biomolecules that can substantially affect host immune responses and surrounding/microbial response. Bacterial EVs have been shown to be involved in the pathogenesis of periodontal disease by destroying gingival tissue, affecting cytokine production transcription, and enhancing a chronic inflammatory response from the host’s innate immune system through activation of the patients’ pattern recognition receptor s, specifically TLRs. In addition, oral bacterial EVs can reach the bloodstream and induce systemic inflammation, providing a potential connection between periodontitis and other conditions such as atherosclerotic cardiovascular disease, diabetes, and rheumatoid arthritis. Consequently, a comprehensive understanding of oral and systemic health concepts is required to reach the full extent of these areas. It is evident that due to recent molecular research, omics technology application, and several developments in the field of nanomedicine, bacterial EVs have shown both clinical and research potential. However, the increased options for isolating EVs have led to questions surrounding potential heterogeneity and the absence of standard tests, among others. Thus, since oral bacterial EVs are re-studied to serve as biomarkers and help develop new periodontal and systemic anti-inflammatory therapies, the trends in future work will consider their newly developed research priorities.
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